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American Society of Microbiology ABMM Sample Questions:

1. Which pattern on a Kirby-Bauer disk diffusion plate, showing resistance of Staphylococcus aureus to erythromycin but susceptibility to clindamycin with a flattening of the clindamycin zone adjacent to the erythromycin disk (D-zone test positive), indicates inducible clindamycin resistance?

A) Indicates the strain should be reported as clindamycin susceptible
B) Indicates the strain possesses an erm gene and should be reported as clindamycin resistant
C) Indicates the strain is tolerant to clindamycin
D) Indicates the strain possesses the msrA gene

2. A clinical microbiology laboratory is using a nucleic acid amplification test (NAAT) to detect Mycobacterium tuberculosis directly from sputum. A positive result indicates:

A) Active tuberculosis disease requiring immediate treatment.
B) The presence of M. tuberculosis DNA, which could be from viable or non-viable organisms.
C) Drug susceptibility information for the M. tuberculosis strain.
D) The presence of viable M. tuberculosis organisms.

3. During the processing of stool specimens for ova and parasite examination, the formalin-ethyl acetate concentration procedure primarily serves to:

A) Stain parasite nuclei for easier identification
B) Preserve parasite morphology and kill bacteria
C) Selectively culture protozoan trophozoites
D) Separate parasites from fecal debris and concentrate them

4. What is considered the "gold standard" for routine monitoring of the lethality of steam sterilization (autoclave) cycles in healthcare facilities?

A) Use of chemical indicator strips placed inside each sterilized pack.
B) Daily check of autoclave cycle printouts for correct time, temperature, and pressure.
C) Regular use of biological indicators containing spores of Geobacillus stearothermophilus.
D) Performing a Bowie-Dick test at the beginning of each day for pre-vacuum sterilizers.

5. A clinical trial is evaluating the efficacy of a new antifungal agent against invasive aspergillosis. Serum galactomannan levels are being used as a biomarker to monitor the infection. A decrease in galactomannan levels during treatment would indicate:

A) Concurrent infection with a non-Aspergillus mold.
B) Successful clearance or reduction of the Aspergillus burden.
C) Development of resistance to the antifungal agent.
D) A false-positive result in the galactomannan assay.

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